![]() ![]() ![]() This global phenomenon has been mainly associated with the dissemination of high-risk clones. Approximately 700,000 people die annually from antimicrobial-resistant infections, and this number is projected to surpass 10 million per year by 2050. The global spread of carbapenemase-producing (CP) Klebsiella pneumoniae (KPC) has become a major threat to human health. Keywords: Klebsiella pneumoniae, KPC-Kp ST307, bla KPC gene, horizontal transfer, Tn4401, glycogen synthesis This study provides a better understanding of the genetic characteristics that can contribute to the growth and spread of KPC-Kp ST307, and their association with antimicrobial resistance genes. Plasmids containing the bla KPC-2 gene could not be artificially removed thus, the three strains could not be cured.Ĭonclusions: The ease of horizontal transfer of KPC-Kp ST307 carbapenem resistance has serious public health and epidemiological implications. The bla KPC-2 gene was located on a truncated Tn4401 transposon. The plasmids could be transferred through conjugation, because all three strains of bacteria contained the type IV secretion system, pilus genes, and tra genes for conjugal transfer. pneumoniae ST307 was horizontally transmitted between these strains. pneumoniae (CPKp1825), Klebsiella aerogenes (CPEa1826), and Escherichia coli (CPEc1827). Three Enterobacteriaceae strains were identified in one patient: K. Results: Sequence analysis of KPC-Kp strain ST307 revealed novel plasmid-located virulence factors, including a gene cluster for glycogen synthesis. Methods: We performed antimicrobial susceptibility testing, PCR analysis, multilocus sequence typing, curing tests, and whole-genome sequencing to characterize plasmid-derived KPC-2-producing Enterobacteriaceae clinical isolates. pneumoniae (KPC-Kp) ST307, investigated the antimicrobial resistance conferred by this strain, and confirmed the horizontal interspecies transmission of KPC- carbapenemase-producing Enterobacteriaceae (CPE) characteristics among Enterobacteriaceae. We analyzed the complete sequences of plasmids from KPC-2-producing K. Background: A lineage of Klebsiella pneumoniae that produces carbapenemase-2 (KPC-2), sequence type (ST) 307, emerged in 2017. ![]()
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![]() Avery had offered his services to Topple and his congregation, and when the church’s choir director moved, Topple called the retired pastor wondering if the offer still stood. Chester Topple, recalled the day he met Avery in Santa Fe. “We are the Church,” for example, could easily be sung during the current pandemic: “The church is not a building, the church is not a steeple, the church is not a resting place, the church is a people.” “Dick and Don were far ahead of their time writing songs for the ages,” Piatt said, adding, “they can be sung today.” “I can attest they were thoughtful, provocative and challenging sermons.” He left behind “boxes of sermons” and “he spoke directly to people,” Piatt said. “He was the consummate preacher,” said Cindy Piatt, the organizing force behind Avery’s remembrance. Included were Isaiah 6:1-8 (“Whom shall I send, and who will go for us?” “Here am I send me!”) and words from Jesus’ Sermon on the Mount found in Matthew 5:13-16 (“In the same way, let your light shine before others, so that they may see your good works and give glory to your Father in heaven.)” Avery himself conducted the choir during at least one song.Īvery selected not only the songs he wanted sung at his service of witness to the resurrection, but the Scriptures he wanted to be read. ![]() One was a virtual choir from Ghost Ranch Education and Retreat Center in Abiquiu, New Mexico, where Avery and Marsh put on workshops for three decades. View their work, housed on the website of the Presbytery of Santa Fe, by clicking here.Ī number of choirs lent their voices as part of the virtual service. ![]() One Sunday, many of the people touched and blessed by Avery’s long and productive years of musical and parish ministry aired an hourlong remembrance of their friend and pastor, who lived to be 85. Marsh, who for decades was Avery’s collaborator at First Presbyterian Church in Port Jervis, New York, died April 10, 2010. Richard Avery, a pastor and half of the prolific songwriting duo Avery & Marsh, died March 15, 2020, in Santa Fe, New Mexico. Presbyterians of a certain age can still sing - still do sing - the songs of Richard Avery and Don Marsh: “Every Morning is Easter Morning,” “Hey! Hey! Anybody Listening?” “We’re Here to be Happy,” “We are the Church,” and so many other songs, memorable for their catchy tunes and their lyrics embracing an authentic faith and calling for justice for all God’s children. ![]() ![]() ![]() Detail info on installation is here: HowToUse AdBlock TypeOfAddon To Block ADs/etc In Basic WebBrowser and HowToUse Basic WebServices in Basic WebBrowser. Inside TB web-browser tab, you may need to stop annoying & privacy-rights violating ADs/deceptions, So you may need to get AdBlock type of addon's XPI file from Mozilla Firefox addons website, and then load that XPI file inside TB if the addon is not available in TB addons website : get uBlock Origin addon, (imo, its better than AdBlock addon in many aspects). If you want to use more (advanced) features from Google-Hangouts web-service (aka: GH network, previously aka: GT network) then do this : TB includes basic web-browser (aka: lightweight web-browser), so a web-browser tab can be opened-up inside TB, and used to connect with Google-Hangouts web-service (aka: GH network) website directly, to send/receive IM messages with your any contacts-list/address-book.TB is created with C, C++, JavaScript, CSS, Rust, XUL, XBL. TB also supports instant messaging and chat using IRC, XMPP, Twitter, (Yahoo-Messenger, Skype, Facebook, etc 1), it can also function as News Client, Feed Reader, etc. But it supports only basic features: text chat. TB has builtin 1 ability/feat to connect with Google-Talk 1/Google-Hangouts 1 text messaging web-service (aka: network). SOLUTION (for Catalina & Mojave users) is, use THUNDERBIRD. Simple & trustworthy, and more uptodate, and more devs supported, and more user supported, etc based TB (since v?) has began to include GPG 1 tool, and from TB v78 (for Windows/Linux/Unix, & different version ? on macOS) it transitioned to use builtin OpenPGP 1, 2, 3, so separate GPG/PGP tool not needed anymore), so user/you can send+receive digitally signed and/or encrypted emails with it, for free. Thunderbird 1, 2 (TB) is a better alternative choice for some of those missing options. ![]() (See detail instruction & goto bottom side for more info, if you have time)ĮXTRA INFO, PLEASE SKIP READING BELOW, IF YOU DON'T HAVE TIME :Īpple has removed many other supports from many other Apple apps, and if you were depended on those, then #Yakyak vs adium mac
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